Database Statistics

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Total Enhancers
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Genome (Human hg38, hg19)
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Tissue Type/Cell Type
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Cell Lines
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Publications

Enhancers by Cell Type (log2 scale)

Enhancers by Tissue Type/Cell Type

Enhancers by Cell Line

Distribution of Experimental Methods

Major Experimental Methods (log2 scale)

Less Common Experimental Methods

Publication Statistics

Total Publications: 35

Publications added to database: Download CSV

Paper Title DOI
CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcriptionhttps://doi.org/10.1101/2024.10.08.616922
High-resolution interrogation of functional elements in the noncoding genomehttps://doi.org/10.1126/science.aaf7613
CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progressionhttps://doi.org/10.1158/0008-5472.can-23-3995
Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAshttps://doi.org/10.1038/s41551-024-01204-8
CRISPR Screening Uncovers a Long-Range Enhancer for ONECUT1 in Pancreatic Differentiation and Links a Diabetes Risk Varianthttps://doi.org/10.1016/j.celrep.2024.114640
A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancerhttps://doi.org/10.1038/s41467-022-31919-8
STAT3-Mediated Promoter-Enhancer Interaction Up-Regulates Inhibitor of DNA Binding 1 (ID1) to Promote Colon Cancer Progressionhttps://doi.org/10.3390/ijms241210041
Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancerhttps://doi.org/10.3390/cancers14071852
Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpathhttps://doi.org/10.1126/sciadv.abi4360
Androgen Receptor-Activated Enhancers Simultaneously Regulate Oncogene TMPRSS2 and lncRNA PRCAT38 in Prostate Cancerhttps://doi.org/10.3390/cells8080864
Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivohttps://doi.org/10.1126/sciadv.abq6324
Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenchttps://doi.org/10.1186/s13059-018-1494-1
Massively parallel disruption of enhancers active in human neural stem cellshttps://doi.org/10.1016/j.celrep.2024.113693
Deciphering essential cistromes using genome-wide CRISPR screenshttps://doi.org/10.1073/pnas.1908155116
TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosushttps://doi.org/10.1038/gene.2016.4
Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions//doi.org/10.1038/s41588-023-01450-7
Landscape of enhancer disruption and functional screen in melanoma cellshttps://doi.org/10.1186/s13059-023-03087-5
Systematic mapping of functional enhancer-promoter connections with CRISPR interferencehttps://doi.org/10.1126/science.aag2445
Downregulation of enhancer RNA AC003092.1 is associated with poor prognosis in kidney renal clear cell carcinomahttps://doi.org/10.1038/s41598-024-64431-8
eNEMAL, an enhancer RNA transcribed from a distal MALAT1 enhancer, promotes NEAT1 long isoform expressionhttps://doi.org/10.1371/journal.pone.0251515
Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activationhttps://doi.org/10.1038/nature12210
Enhancer RNA - P2RY2e induced by estrogen promotes malignant behaviors of bladder cancerhttps://doi.org/10.7150/ijbs.27151
Super-enhancer-associated long noncoding RNA AC005592.2 promotes tumor progression by regulating OLFM4 in colorectal cancerhttps://doi.org/10.1186/s12885-021-07900-x
Enhancer RNA-driven looping enhances the transcription of the long noncoding RNA DHRS4-AS1, a controller of the DHRS4 gene clusterhttps://doi.org/10.1038/srep20961
The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinomahttps://doi.org/10.1038/s41419-023-06047-w
Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progressionhttps://doi.org/10.1038/s41419-023-05892-z
Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progressionhttps://doi.org/10.1038/s41467-018-06081-9
Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNAhttps://doi.org/10.1038/ncomms7520
JUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasishttps://doi.org/10.1038/s41419-023-05985-9
The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemiahttps://doi.org/10.1182/blood.2018874503
Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasishttps://doi.org/10.1158/0008-5472.CAN-23-0544
Carcinogen-induced super-enhancer RNA promotes nasopharyngeal carcinoma metastasis through NPM1/c-Myc/NDRG1 axishttps://pmc.ncbi.nlm.nih.gov/articles/PMC10492133/
RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activationhttps://doi.org/10.1038/s41594-018-0102-0
Complementary Alu sequences mediate enhancer?promoter selectivityhttps://doi.org/10.1038/s41586-023-06323-x
The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5phttps://doi.org/10.1186/s12943-018-0894-x